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Tolbutamide’s conversion to inactive metabolites has been shown to be catalyzed by xanthine oxidase from rat liverThe clinical significanceif anyof these observations is unknown.
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Renal failure in association with administration of Zyloprim has been observed among patients with hyperuricemia secondary to neoplastic diseasesConcurrent conditions such as multiple myeloma and congestive myocardial disease were present among those patients whose renal dysfunction increased after Zyloprim was begunRenal failure is also frequently associated with gouty nephropathy and rarely with hypersensitivity reactions associated with ZyloprimAlbuminuria has been observed among patients who developed clinical gout following chronic glomerulonephritis and chronic pyelonephritis.
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